Science

SMSbiotech has developed a patented technology (US Patent No. 10,041,037) that can bio-manufacture human ECM, derived from Small Mobile Stem (SMS) cells, in large, industrial-scale quantities. Our technology will provide patients with access to high-quality, immuno-compatible, and affordable human (allogenic or autologous) ECMs. We have established proprietary techniques for the isolation and indefinite growth of native adult SMS cells. Consistent with their true stem cell characteristics, these cells have not been transformed or manipulated. This technology also enables the high-volume and reproducible production of ECMs. Our technology will help facilitate the development of cost-effective methods for (1) skin regeneration, (2) vascular repair, and (3) scaffold and tissue engineering. All of these processes are essential for the rapid, safe, and effective healing of wounds to any organ.

Upcoming Presentations

August 25-27, 2019 – San Diego, CA, USA

Past Presentations

June 5-7, 2019 – Baltimore, USA

Title: ANGIOstream: A novel Angiogenesis in vitro assay system
Presenter: Abdulkader Rahmo PhD

“The Extracellular matrix is an essential component of in vivo Angiogenesis. Current in vitro Angiogenesis assays capture only early stages of micro-vessel formation. A unique Angiogenesis assay system (ANGIOstream) that uses a proprietary human extracellular matrix, derived from small mobile stem cells, is able to apply merely regular human primary endothelial cells to capture and monitor, in vitro, a complex multi-stage, multi-step process of developing micro vessels into macrovessels. The large vessels become visible to the naked eye. This capability would provide, first-time, ample opportunities for interrogating anti-Angiogenesis drugs, in vitro, at significantly more mature stages of vessel formation.”

5th World Congress on Cell & Stem Cell Research, 2015

Title: Relevance and scope of SMS derived Multicellular Micro Machines (M3) in Native tissue reconstruction.
Presenter: Abdulkader Rahmo, PhD

“The newly discovered Small Mobile Stem (SMS) cells exhibit the extraordinary ability to form diverse complex cooperative multicellular assemblies. These assemblies have a demonstrated aptitude for engineering tissue like structures in an in vitro cell culture set up. The observed approach to construction can be ascribed to a top down modus operandi at a micro level. It is executed by units we designated as Multicellular Micro Machines (M3). To explore the relevance and scope of this in vitro discovery, for the in vivo case of tissue reconstruction, M3 assemblies and their traces were hunted in a broad variety of native tissues. Results indicate the importance of implicating the M3 mediated mechanism in native tissue reconstruction; and demonstrate hence the fundamental role of SMS cells.”

2nd International Conference and Exhibition on Cell and Gene Therapy, 2013

Title: “Multi cellular Micro Machines” derived from a newly discovered Human adult stem cell: A new paradigm in tissue
reconstruction?
Presenter: Abdulkader Rahmo, PhD

“We have recently introduced a novel human adult stem cell type: Small, Mobile Stem cells (SMS cells), exhibiting exceptional characteristics conducive to morphogenesis in standard media conditions. We have outlined and defined details of several complex new processes, in a simple parametrically “poor” set up. In vitro and de novo established macrostructures demonstrate high regenerative potency. The observed structures appear to be highly relevant to multiple tissues of in vivo model systems. Observed complex in vitro constructive activity is mediated by unit assemblies of cooperating cells which we designate as Multi-cellular Micro Machines (M3). M3 are built by cells derived from cultured SMS cells. They emanate reproducibly in vitro and can be phenotypically categorized according to constructive activity. M3 are not artificial constructs of the in vitro SMS cell system, but are representative of recurring components of diverse native tissues. The choreographic self organization of SMS cells and their derivatives into various functional multicellular (M3) units is suggestive of autoinduced and autopoietic processes typical of organ genesis. Exploring these tissue constructive actors would usher a new era in tissue engineering, and enhance prospects for autologous tissue transfer.”

Literature

ANGIOstream™ White Paper

ANGIOstream™ is a unique angiogenesis assay system that uses proprietary human extracellular matrices and primary endothelial cells to capture and monitor the complex, multi-stage, multi-step process of stable micro and large macrovessel formation in vitro. The complete process of vessel formation can easily be monitored in the “dish”, without system disruption, and can be explored using chosen substances.”

Insights

Extracellular Matrices and Aging

Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair.
Authors: Witjas FMR, van den Berg BM, van den Berg CW, Engelse MA, Rabelink TJ.

Extracellular Matrix Modulates Morphology, Growth, Oxidative Stress Response and Functionality of Human Skin Fibroblasts during Aging In Vitro
Authors: Peter Jørgensen and Suresh Rattan

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials
Authors: Marsha C. Lampi and Cynthia A. Reinhart-King

The extracellular matrix as a multitasking player in disease
Authors: Achilleas D. Theocharis, Dimitra Manou, and Nikos K. Karamanos

The extracellular matrix: Structure, composition, age-related differences, tools for analysis and applications for tissue engineering
Authors: Jaspreet K Kular, Shouvik Basu, Ram I Sharma

Extracellular Matrices and Cancer

Complex mechanics of the heterogeneous extracellular matrix in cancer
Authors: Andrea Malandrinoa, Michael Mak, Roger D. Kamm, Emad Moeendarbary

Role of Extracellular Matrix in Development and Cancer Progression
Authors: Cameron Walker, Elijah Mojares, and Armando del Río Hernández

Extracellular Matrices and Tissue Repair

The Role of the Extracellular Matrix Components in Cutaneous Wound Healing
Authors: Pawel Olczyk, Łukasz Mencner, and Katarzyna Komosinska-Vassev

Biomaterials for tissue repair
Author: Karen L. Christman

Human Health Concerns

Diabetic Ulcer:
Financial burden of diabetic foot ulcers to world: a progressive topic to discuss always
Authors: Alok Raghav, Zeeshan Ahmad Khan, Rajendra Kumar Labala, Jamal AhmadSaba NoorBrijesh Kumar Mishra

Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis
Authors: Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y

Cancer:
The Role of Angiogenesis in Cancer Treatment
Authors: Mehdi Rajabi and Shaker A. Mousa

Stem cells in cancer therapy: opportunities and challenges
Authors: Cheng-Zhang, Ting Huang, Bi-Li Wu, Wen-Xi He, and Dong Liu