Mesenchymal stem/stromal cells (MSCs) are typically characterized by their ability to differentiate into skeletal (osteogenic, chondrogenic and adipogenic) lineages. MSCs also appear to have additional non-stem cell functions in coordinating tissue morphogenesis and organizing vascular networks through interactions with endothelial cells (ECs). Findings demonstrate the intrinsic self-organizing properties of MSCs, which may broaden their use in regenerative medicine and advance current approaches.