Analysis of the Intrinsic Self-Organizing Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells

Analysis of the Intrinsic Self-Organizing Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells

Mesenchymal stem/stromal cells (MSCs) are typically characterized by their ability to differentiate into skeletal (osteogenic, chondrogenic and adipogenic) lineages. MSCs also appear to have additional non-stem cell functions in coordinating tissue morphogenesis and organizing vascular networks through interactions with endothelial cells (ECs). Findings demonstrate the intrinsic self-organizing properties of MSCs, which may broaden their use in regenerative medicine and advance current approaches.

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