COVID-19 Can Infect Human Brain Organoids

COVID-19 Can Infect Human Brain Organoids

In a preliminary, not-yet-peer-reviewed study posted June 26 to bioRxiv, a team of Yale University researchers report that SARS-CoV-2 is capable of infecting and replicating in neurons in human brain organoid models. While the finding is consistent with two other, smallerstudies, there’s no clear evidence so far that the virus can infect brains.

It’s becoming increasingly clear that COVID-19 causes not only respiratory ailments, but also a wide variety of neurological symptoms—from the common phenomenon of losing taste and smell, to more recent reports of ischemic stroke, delirium, and hallucinations—raising questions of whether such symptoms are a byproduct of various disruptions SARS-CoV-2 causes throughout the body, a consequence of the trauma of being hospitalized with COVID-19, or if they could be due to viral invasion of neural tissues.

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July 13, 2020
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