Proof of Concept Studies:
SMS cells were tested on different animal models pertinent to degenerative diseases such as:
Patients with diabetes have a 25% likelihood to develop a foot ulcer. Some of these do not heal using the standard care of medicine, resulting in open wounds that remain as such for very long periods. These wounds are susceptible to microorganismal invasion that could lead, consequently, to amputation of the limb. Patients with a prior amputation have a very low life expectancy.
The model organism used is a mouse strain with a strong diabetic phenotype (BKS.Cg- Dock7m +/+ Leprdb//J) that causes significant delays in skin wound healing. Two excision wounds were inflicted; one was treated, and the other was used as a control. The wounds were splinted to prevent healing by skin contraction.
Applying extracellular matrix (proteins) derived from SMS cells on wounds resulted in a large increase (multiple ratios) in granulation, epithelialization, and capillarization of the healing tissue extracted after 14 days.
Progressive Lung Degeneration
A chronic, inflammatory lung disease that causes obstructed airflow from the lungs. Emphysema (caused by the destruction of air sacs, and alveoli) and Chronic Bronchitis are the most common conditions that make up COPD. Symptoms include breathing difficulties, cough, mucus, and wheezing. It is caused typically by long-term exposure to breathable irritants. The disease is progressive and currently irreversible. Patients are at increased risk of developing heart disease, lung cancer, and a variety of other conditions.
The model organism used is an elastase enzyme-treated rat. The enzyme damages a significant number of lung air sacs (alveoli) mimicking the case of lung emphysema in patients.
Testing the effect of SMS cells instilled into the lung of this rat resulted in a high percentage of alveoli regeneration using a mere single dose of SMS cells. Different regiments are currently being studied to optimize the healing effect of these cells.
Animal Safety Studies
SMS cells were tested in different animals and different genders regarding safety. Using large numbers of human SMS cells injected into different regions (organs, tissues) of the animal and by applying various regimens, no adverse effects at tissue, organ, or organismal level were detected.
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Sun Z, Li F, Zhou X, Chung KF, Wang W, Wang J. Stem cell therapies for chronic obstructive pulmonary disease: current status of pre-clinical studies and clinical trials. J Thorac Dis 2018;10(2):1084-1098. doi: 10.21037/jtd.2018.01.46