Small Mobile Stem (SMS) Cells:
SMSbiotech has developed a patented technology to isolate human Small Mobile Stem (SMS) cells from adult tissue. SMS cells have many unique features including small size, mobility, and extensive proliferation potential. SMS cells present also extraordinary chemical and physical resilience that facilitate handling, operation, and tissue administration.
SMS cells interact strongly with various other adult cells such as vascular endothelial cells, fibroblasts, Alveolar Type II lung cells, and mesenchymal stem cells (of different tissue origin). In vitro data suggest these interactions could be critical for establishing a pleiotropic mechanism for human in vivo organ repair and regeneration.
Small Mobile Stem (SMS) cells have been shown in animal experiments to promote the repair and regeneration of various damaged tissue and organs. Unlike other adult stem cells, such as mesenchymal stem cells, that have scaling limitations, SMS cells have extensive proliferation capacity and are being used to produce large amounts of cells with stable quality. SMS cells present very few, if any major histocompatibility proteins, which makes them significantly less immunogenic than even MSCs [more ways SMS cells differ from MSCs]. The application of SMS cells of allogeneic sources, grown and manufactured under GMP conditions, is proposed as a potential, off-the-shelf effective treatment that could repair critically damaged tissues.
SMS cells were discovered in peripheral blood. As such, they can reach any part of the body. SMS cells are the only known cells that bind to and stimulate the proliferation of key cells needed for lung regeneration: alveolar cells, endothelial cells, and extracellular matrix essential to the air sac (alveoli) walls.
The unique resilience and size of these cells allow for direct administration to the lung using a nebulizer (inhaler). This will reduce potential side effects on other organs and allow optimal, targeted regeneration.
Transportation and manufacturing of SMS cells are efficient processes that will reduce logistical challenges and increase availability.
Extracellular Matrix (ECM):
Extracellular Matrix (ECM), a complex composite substance, is a major component of our body, it constitutes 70% of the skin. It is the hub for the repair and regeneration of the skin. SMSbiotech developed the PATENTED technology to bio-manufacture human ECM derived from Small Mobile stem cells, in large, industrial-scale quantities. Providing patients access to high-quality, immuno-compatible, and affordable human (allogenic or autologous) ECM.
A unique angiogenesis assay system that uses a proprietary human extracellular matrix and primary endothelial cells for the in vitro capturing and monitoring of the complex multi-stage, multi-step process of stable micro and large macro-vessels formation. The complete process of Vessel formation is easily monitored in the “dish” without system disruption. This allows the researcher to examine in detail the effect of chosen substances on the formation of these vessels.